A unique clinical case was reported at the National Institutes of Health Hospital in Bethesda. The first time a 47-year-old woman was admitted to hospital with COVID-19 in the spring of 2020. Three years before that, she had undergone successful lymphoma treatment.
Nine months later, during the next examination, she again confirmed the coronavirus, while the patient had no symptoms of the disease. At first, doctors suggested that the test gave a false-positive result, but a month later, the woman again confirmed COVID-19, and the viral load increased.
Genome sequencing showed that this is the same virus that was detected in the patient in 2020, that is, it was not a re-infection. The woman again underwent treatment for coronavirus, and only 335 days after infection, she received a negative test.
According to doctors, long-term circulation of the virus in the patient’s body is associated with the treatment of cancer. The patient received CAR-T cell therapy, which uses the patient’s own cells to destroy malignant cells. The treatment helped fight the cancer, but at the same time lowered the level of B cells involved in the production of neutralizing antibodies.
Earlier, scientists from the United States described several cases of “unkillable” coronavirus in both adults and children with weakened immunity due to cancer. A five-year-old girl was ill with coronavirus for three months, a boy of the same age – 196 days, pulmonary lesions persisted for up to 250 days. The most severe case was in a young man, 20-25 years old, who was receiving chemotherapy at the time of infection. The infection remained in his body for 250 days, along with severe symptoms.
All patients suffered from acute B-cell leukemia, a form of blood cancer in which the body virtually stops producing B-cells.