To assess the likelihood of a severe course of COVID-19 after a “breakthrough” infection, scientists at the University of Nottingham analyzed the medical records of UK residents who received one or two doses of the vaccine from December 2020 to June 2021. The researchers recorded all cases of infection, hospitalization and death within 14 days after vaccination.
In total, about 7 million Britons from 19 to 100 years old have been fully or partially vaccinated. During the observation period, 2,000 deaths from COVID-19 and 1,900 hospitalizations among those vaccinated with one component were recorded, as well as 81 deaths and 71 hospitalizations among those fully vaccinated.
Patients with Down syndrome have the highest risk of severe course, need and mortality – people with this disease end up in hospitals and die 12.7 times more often than the general population. Increased vulnerability to “breakthrough” infection and its consequences was also revealed in people who underwent kidney transplantation (increase by 8.1 times), suffering from sickle cell anemia (7.7 times), receiving chemotherapy (4.3 times), with HIV / AIDS (3.3 times).
Scientists also attributed to risk groups residents of nursing homes, patients with dementia, liver cirrhosis, severe neurological diseases, Parkinson’s disease, epilepsy, chronic kidney disease and other serious pathologies.
As for ethnic groups, most often after a “breakthrough” infection, patients of Indian and Pakistani origin end up in hospitals, which more often. According to the authors of the study, there is nothing to do with genetic predisposition: representatives of these nationalities mainly live in large families in cramped conditions, which significantly increases the risk of transmission of the virus.