Oct 26, 2021
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The master of the Kremlin is preparing for a revaccination. Isn’t it dangerous? What do the doctor’s say

The master of the Kremlin is preparing for a revaccination.  Isn't it dangerous?  What do the doctor's say

Photo: Egor Aleev / TASS

Reportedly, after the adoption of the decree on non-working days at the beginning of November, the plans of the President of the Russian Federation Vladimir Putin on the celebration of National Unity Day on November 4 may be adjusted. This was announced by the press secretary of the head of state Dmitry Peskov… “There are certain plans, there were, they were made up, but, perhaps, they will be corrected,” the Kremlin spokesman said. So, according to Peskov, the President plans to be revaccinated against coronavirus on November 4. But will the Russians see the revaccination footage directly? This, according to the press secretary, will depend on the opinion of Vladimir Vladimirovich himself. As of today, it is known that Putin was vaccinated with two components of the Sputnik V vaccine in the spring of this year. At the same time, the president decided not to demonstrate his vaccination in March and April this year. And whether his opinion changed during the planned vaccination on November 4, Dmitry Peskov, according to him, is also unknown.

“As he decides, so it will be, – said the press secretary. At least, the President of Russia has not yet made a direct decision on revaccination. As Peskov noted earlier, this requires expert advice. Meanwhile, the question of re-vaccination really worries doctors and specialists from the scientific community today. At least revaccination against coronavirus earlier than six months after the initial vaccination, they believe, is not dangerous to the body. The same opinion is held by doctor immunologist-allergist Vladimir Bolibok… True, he is sure that it is still better not to rush with the introduction of the second component of the vaccine. “A certain interval, of course, must be observed. But there is no need to do a revaccination every week – it will not lead to anything good, ”stressed Vladimir Bolibok. However, he also warned Russians against frequent vaccination against coronavirus President of the Russian Scientific Society of Immunologists and Scientific Director of the Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences Academician Valery Chereshnev, who warned that re-immunization against COVID-19 earlier than six months after the first vaccination can turn into the so-called immunological paralysis – a sharp suppression of the body’s defenses.

By the way, this term (“immunological paralysis”), according to Vladimir Bolibok, was introduced at the beginning of the year before last – the beginning of the last century by the scientist microbiologist Alexander Bezredka, student Ilya Mechnikov… He, in fact, invented a system for administering immune serum to combat diphtheria in order to achieve the very immunological paralysis so that the patient, according to the immunologist-allergist, does not develop anaphylactic shock. This technology, says Bolibok, was revolutionary for the time when there were no antibiotics or vaccines. Therefore, the serum was made from the blood of horses, which could cause a deadly reaction in humans, for which he was injected into a state of immunological paralysis.

As for the relevance of the problem of today – revaccination against coronavirus, we talked on this topic with public health expert, immunologist Nikolai Aleksandrovich Kryuchkov

“SP”: – Nikolai Alexandrovich, there is an opinion of experts that too frequent revaccination is harmful and dangerous. What do you think about this?

– The main problem here is to determine: too often – how is it? That is, it is obvious that if you inject the vaccine every day, then it will not be beneficial. And if you do it every six months, I think that most likely not, it is not dangerous. If a person is initially healthy and does not have a clinical diagnosis, secondary immunodeficiency, and even more so primary, and he is not on hormonal or other severe therapy, then, accordingly, he should not have problems with this.

I have, of course, heard about my colleague’s recent statement about immunological paralysis. But it seems to me that this is more of an allegory. As for not injecting the vaccine every week, this is obviously the case. They do not need to be done with such frequency. But twice every six months, in my opinion, this is still quite acceptable. The question is what vaccines are used, because the drugs are all different. That is, I would not approach this question without research. It is clear that specialists have some concerns about this. Here you need to understand that all the drugs administered are not the same. The common people call them in one word: “vaccines”. In fact, they are very different. Adenoviral vaccines are one thing, recombinant subunit or inactivated vaccines or some other types of vaccines are another. They are all different and work a little differently. Therefore, it is necessary to clarify which vaccines should not be used often and how often. That is, all this is not entirely clear and, most likely, such terrible effects as immunological paralysis, which my colleague said about, will not happen. Even if you do two revaccinations in six months and, at the same time, not for five years, then, accordingly, nothing terrible will happen.

In this case, what are we talking about? Now the first vaccination against Covid is underway, and at the same time they are still doing it against the flu, Pneumococcus, and six months later – the first revaccination (or the person gets sick during this period). There is no talk about the fact that every six months for several years people will be injected with these vaccines. In the meantime, we are talking about a single revaccination. And now they are already beginning to consider the issue of repeated revaccination, that is, about the second. But not about the third, not about the fourth, not about the fifth. From this point of view, a normal healthy person is afraid of any immunological paralysis, it seems to me, is not worth it. Even children are given multiple injections of different vaccines over a limited period of time, such as during the first year of life. Their immune system does not go into immunodeficiency. And in principle, this cannot happen, because the vaccine imitates, to some extent, infection. But after all, people constantly encounter various infections: with intestinal infections, and with acute respiratory viral infections, and herpes …

“SP”: – However, some ordinary people believe that the more often you revaccinate, the more antibodies will be. Is it so?

“NK”: – We like to constantly rush from one extreme to another. No. The fact is that, relatively speaking, we have developed immunity to the variant of the coronavirus antigen. A little time passes, our immunity is still on the rise. We have enough antibodies, including neutralizing ones, there are cells that are produced by the immune system, not only memory, but also vector cells that react directly with antigens of a possible coronavirus infection. And at this time we are still boosting the immune system. What for? It is impossible to obtain protection greater than maximum. Right now you have, relatively speaking, 800 BAU / ml of antibodies, and then, let’s say, you raised their level to 1400. But the fact that you have 1400 and not 800 does not mean that your real clinical protection will be higher … This is absolutely not the case. That is, a certain sufficient level of protection is achieved. Yes, in the beginning, when the number of antibodies grows, the protective function of the vaccine and immunity grows proportionally. But then, upon reaching a certain level, protection is no longer added even against an increase in the number of antibodies. This is completely unnecessary and really overloads the immune system. Why exactly 6 months is the recommended interval before revaccination, I have voiced many times in the media.

The point is that from what we now know, this is, relatively speaking, the optimal period of time during which, on the one hand, the majority of people who receive this vaccine will thus receive a real additional clinical benefit, and on the other – no security problems increase. For certain categories of the population, for example, for the elderly in some countries, it is recommended to do revaccination even more often than after six months. And for people with immunodeficiencies, special vaccination programs are being developed. For them, for example, not two, but three vaccines at once are done at certain intervals. But this is an individual story. For the vast majority of people, this is not relevant. Therefore, 6 months is the optimal period. It is for this period that their immunity is highly likely to protect them.

In short, everyone makes a decision for themselves on an individual basis. But in general, based on the aggregate opinion of experts, at the moment six months is still an objectively suitable time for the majority of the population to protect themselves from coronavirus and undergo revaccination.

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