Substances produced by bacteria may be associated with the likelihood of developing vascular anomalies.
In animal studies, scientists have already shown that substances that secrete intestinal bacteria can enter the brain with blood and cause pathologies in its vessels. Now, for the first time, scientists have found a direct relationship between the risk of hemorrhagic stroke and intestinal microbiome in humans. New study published in The bonds of nature,
Scientists have collected fecal tests in more than 100 patients with cavernous angioma. This is vascular malformation (defect, anomaly) that occurs in approximately 0.5% of people. It can cause epileptic seizures and cerebral hemorrhages (hemorrhagic strokes). There is evidence that such angiomas appear in people aged 30-50 years.
It turned out that the presence of angiomas in the brain is closely related to certain indicators of the intestinal microbiome. Among the main characteristics, scientists called the number Odoribacter splanchnicus above average and reduced concentrations Faecalibacterium prausnitzii and Bifidobacterium,
Patients with cavernous angioma, regardless of how they took the material for the study, had a similar microbiome, said Issam Awad, professor at the University of Chicago, co-author of the study. This did not depend on whether the angiomas in the study participants were a product of hereditary mutations or if they were sporadic cases.
Further analysis showed that the concentration of certain substances in the body depends on the microbiome. Scientists have discovered increased synthesis of certain lipopolysaccharides in people whose microbiome is associated with cavernous angioma. Before that, scientists discovered a similar phenomenon in mice. In animal studies, it was shown that such molecules are introduced into the brain with blood flow and stimulate the development of cavernous angiomas.
It is noteworthy that the analysis of bacterial populations in the intestine and the measurement of the level of certain biomarkers in the blood in the framework of this study gave tremendous accuracy in diagnosing the severity of cavernous angioma.
Scientists do not expect that in the near future there will be a probiotic or antibiotic that can help in the treatment of this condition. They fear that the action of such substances may spread beyond the necessary strains of bacteria. Therefore, it is now impossible to fully predict the effects of such treatment.